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What are the dissolution methods of hydroxypropyl methylcellulose (HPMC)?

November 25, 2021by admin0

What are the dissolution methods of hydroxypropyl methylcellulose (HPMC)?

Hot water dissolution method: Since HPMC does not dissolve in hot water, HPMC can be uniformly dispersed in hot water at the initial stage, and then quickly dissolved during cooling. Two typical methods are described as follows:
1) Put the required amount of hot water in the container and heat it to about 70°C. Gradually add hydroxypropyl methylcellulose with slow stirring, start HPMC floating on the surface of the water, then gradually form a slurry, and cool the slurry with stirring.

2). Add 1/3 or 2/3 of the required amount of water into the container and heat it to 70°C. Follow the method in 1) to disperse HPMC to prepare a hot water slurry; then add the remaining amount of cold water to hot water In the slurry, cool the mixture after stirring.

Powder mixing method: Mix HPMC powder with a large amount of other powdery ingredients with a blender, and then add water to dissolve, then HPMC can be dissolved at this time without clumping and agglomerating, because each tiny corner contains only a little HPMC The powder will dissolve immediately when it meets water. —— Putty powder and mortar manufacturers use this method. [Hydroxypropyl methyl cellulose (HPMC) is used as a thickener and water retention agent in putty powder mortar. ]


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